“I have been on high dose of tE2 for almost 2 years now. It has been a great experience, with none of the bad side effects from LHRH ADT drugs. I have been able to continue my high school refereeing of football, soccer, and beach volleyball games.”
– Bob C. (72), Arizona
“I started using estradiol gel in June, 2025 for preventing osteoporosis. Thanks to tE2, I have much better sleep, no cramps in legs and feet (which bothered me for 2 years), and reduced brain fog as the main benefits.”
– Ashok (80), New Delhi (India)
“I felt an almost immediate improvement in mood when I began using tE2. My moderate hot flashes disappeared completely within a couple of months, and at 4 months I felt there was improvement in my libido. I believe my Quality of Life has improved since starting transdermal estradiol.”
– Tim (73), Ontario (Canada)
“I am now going on the 6th year of using this estradiol ADT protocol and have maintained my PSA around 0.04. I have not had any problems with estradiol side effects, other than a moderate amount of breast enlargement and sensitivity. I have had none of the typical side effects that I previously experienced with Lupron ADT.”
– Lance, Wyoming
“After a few months on Orgovyx ADT, I switched over to tE2 ADT. My previous side effects on tE2 improved and the cancer suppression was identical to Orgovyx ADT. I am now maintaining a PSA below 0.014 ng/mL on tE2 ADT. These results made tE2 a clear choice for me.”
– Larry (77), Alaska
“The only issue with transdermal estradiol (tE2) has been annoying, but manageable, gynecomastia I seem to be in technical remission now. I have had no night sweats or cardiac arrhythmias. So, tE2 will be with me for the rest of my days to keep the wolf at bay.”
– Peter (74), Ontario (Canada)
“I’m now using subdermal implanted estradiol pellets, in place of estradiol patches. My bone density has become normal and stable, and I have no hot flashes, good memory, and plenty of energy. My PSA remains undetectable for almost 7 years now.”
– Jerry (68), Michigan
“Using estradiol patches, I have had no significant side effects, and my PSA and testosterone levels have dropped to nearly zero in 3 months. Gynecomastia has been the only side effect. As someone with other comorbidities, I appreciate how it is equally effective with significantly fewer short and long-term side effects. I am thankful my oncology team was open to proven therapies outside of what the FDA has currently approved.”
– Andrew (63), Utah
“As I switched to the estradiol patches, my quality of life became much, much better. The downside is that I now have breast growth, but I am OK with this problem.”
– Arthur (68), Florida
“Within days [of using an estradiol patch], the waking up 5-7 times a night from hot flashes was almost gone and my desire to live returned. As a medical doctor, I am upset that so few of my colleagues offer, or even know about, the effectiveness and safety of estradiol patches.”
– Michael (71), California
“The hot flashes, fatigue, and sleep interference caused by Lupron ADT disappeared with re-institution of transdermal patches, and a good Quality of Life was restored.”
– Paul (84), Virginia
“I started low-dose estradiol after being prescribed Lupron and Erleada for stage-IV prostate cancer. I was having regular hot flashes, which were an irritant. Once I started the E2 patches, these completely went away. The patches are 0.1 mg, changed twice weekly. Last summer I stopped using the patches, but the hot flashes returned.”
– John (80), Arizona
“I have never had a hot flash or any other typical ADT side effect with a single estradiol patch, with the exception of minor (unnoticeable) gynecomastia. My PSA varies between 0.02 and 0.07. I am grateful every day to be spared the tribulations commonly associated with prostate cancer.”
– Robert (81), Texas
“I am very happy with using high-dose estradiol gel while I was also on Orgovyx ADT for 6 months. I had no hot flashes while using E2 gel, and my bone mineral density (@ lumbar spine) increased by 10% during the 8 months that I was using the estradiol gel. I also liked how inexpensive the compounded gel product was (about $1/day). I now have some mild breast growth, but I’m used to it and it’s no big deal.”
– Bob W. (71), New Mexico
“Transdermal estrogen offered a different option, so I pursued it as an alternative form of ADT. With my oncologist later adding Zytiga for a double hormone blockade, the result has been effective cancer control and about 6% more bone density today than when I was diagnosed.”
– Russ (63), Arizona
“With the addition of a low dose tE2 patch (25 mcg/day), after 3 months I had noticeably more energy, significant improvement in memory and brain function, and overall improvement in my quality of life. I’m sticking with this for sure!”
– Mike (73), Alberta (Canada)
“I hated how I felt on Lupron and started looking around for an alternative form of ADT. I found my way to transdermal estradiol (tE2) and have been on it almost continuously now for over 22 years. No hot flashes, no osteoporosis, and I sleep better. As long as I stay on tE2, my PSA remains below the detectable limit. For me, tE2 has transformed my prostate cancer into a chronic manageable condition and, as long as my PSA stays down, I have no interest in stopping my use of tE2 for ADT.”
– Richard (80), British Columbia (Canada)
“The only SE I’m experiencing is minor breast soreness and some increase in breast size. No hot flashes, no brain fog, no mood fluctuations, and hopefully no bone loss. End of this year marks my 6th anniversary from diagnosis. I’m enjoying my 80th year of life immensely. Quality of life is the most valuable thing to me and my wife. I’m a never Chemo, PARP, fellow…and likely not radiation ligand.
– Gary (80), South Africa